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Hown in Figure 2A, pretreatment with SP600125 (1 M) significantly inhibited the LTAinduced proMMP-9 expression during the period of observation. Moreover, LTA-induced MMP-9 mRNA expression was also significantly blocked by pretreatment with SP600125, determined by RT-PCR (Figure 2B). To further determine whether LTA-induced proMMP-9 expression was mediated through JNK1/2 phosphorylation, the kinet
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