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Ds virulent forms and can be local reactions at the usedDs virulent forms and can be local reactions at the used in immunodeficient hosts; not vaccine site) are required heat-labile to optimally trigger the adaptive immune system and generate long-term immunity; do not give rise to cytotoxic T cells; poor induction of mucosal immunity; difficult to produce in a scalable setting; quality and
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That provides selection and propagation in host bacteria. Although the exactThat provides selection and propagation in host bacteria. Although the exact mechanism by which DNA vaccines work still remains unclear recent advances have provided a deeper , understanding of the molecular and immunological [12-14] mechanisms of action of these vectors . Generally, once the DNA plasmid is administe
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Ed vaccines) or viruses (inactivated vaccines) inactivated by chemical or physicalEd vaccines) or viruses (inactivated vaccines) inactivated by chemical or physical treatmentsToxoids vaccinesPurified exotoxins chemically inactivated into toxoids that retain the ability to induce toxin-neutralizing antibodiesSubunit/ polysaccharide vaccinesAntigenic components of pathogens: partly or fully pu
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D proteins may be processed in transfectedWJV|www.wjgnet.comAugust 12, 2015|VolumeD proteins may be processed in transfectedWJV|www.wjgnet.comAugust 12, 2015|Volume 4|Issue 3|Trovato M et al . Vaccine delivery systemsTable 1 Overview of the different vaccine formulationsVaccine type Live attenuated vaccines Description Advantages Disadvantages Immunogenicity Humoral and cytotoxic immune resp

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